Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes

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Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes

OBJECTIVE To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS The risk of serious adverse outcome at different A1C levels was compared with the background population. The ...

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Evaluation of Antiphospholipid Antibodies and Activated Partial Thromboplastin Time in Women with Adverse Outcome of Pregnancy

Adverse outcome of pregnancy is a potentially dangerous complication of conception and affects 15-20% of pregnancies. According to recent studies increased level of blood antiphospholipids antibodies, if accompanied by predisposing factors, can be an adverse event in human pregnancy. The aim of the present study was to compare the maternal serum levels of anticardiolipin and antiphosphatidyl se...

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Non-glycemic-dependent reduction of late pregnancy A1C levels in women with type 1 diabetes.

A reduction of A1C levels during pregnancy in women without diabetes has been reported (1–6), suggesting that the goal for A1C during pregnancy complicated with diabetes should be lowered. The decrease in fasting blood glucose levels during the first trimester of normal pregnancy (7,8) may explain the lower A1C levels found in early pregnancy (1,2,3,5). A further decrease of A1C in late pregnan...

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Adverse pregnancy outcomes in women with diabetes

Pregnancy affects both the maternal and fetal metabolism and even in nondiabetic women exerts a diabetogenic effect. Among pregnant women, 2 to 17.8% develop gestational diabetes. Pregnancy can also occur in women with preexisting diabetes, that can predispose the fetus to many alterations in organogenesis, growth restriction and the mother to some diabetes-related complications like retinopath...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2009

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc08-2061